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NCID > About NCID > Leadership > Professor David Lye

Professor David Lye

Professor David Lye

Dr David Lye.jpg

Infectious Disease Research and Training Office


Clinical interests
Antimicrobial resistance, general and nosocomial infections, bone and joint infections, HIV medicine, tropical infectious diseases

Language(s) spoken
English, Mandarin, Malay, Cantonese


Professor David LYE Chien Boon (MBBS, FRACP, FAMS, FRCP) graduated in medicine on the Dean's List from the University of Melbourne in 1996 and completed specialty training in infectious diseases in Australia in 2004. He returned to Singapore to work at the Department of Infectious Diseases, Tan Tock Seng Hospital (TTSH) in 2005.


Professor Lye is Director of Infectious Disease Research and Training Office at the National Centre for Infectious Diseases (NCID), professor at Lee Kong Chian School of Medicine and acting deputy executive director, Programme for Research in Epidemic Preparedness and Response (PREPARE), Ministry of Health, Singapore. He is senior consultant, Department of Infectious Diseases, TTSH and associate professor at Yong Loo Lin School of Medicine. At TTSH, he founded and led the Antimicrobial Stewardship Programme from 2009 to 2018. At NCID, he headed Singapore Infectious Disease Clinical Research Network (SCRN) from 2014 to 2020, and Training and Education Office from 2018 to 2020.


He has been the chair of the National Antimicrobial Stewardship Expert Panel since 2014.  He is a member of National Antimicrobial Resistance Control Committee, One Health Antimicrobial Resistance Project Team and Expert Committee on COVID-19 Vaccination, Ministry of Health, Singapore.


Professor Lye has held more than SGD$12million in research grant as principal investigator to date. His research interests are in COVID-19, dengue and antimicrobial resistance. He has published more than 290 peer-reviewed manuscripts in journals such as NEJM, Lancet, JAMA, Lancet Respiratory Medicine, Lancet Infectious Diseases, Lancet Global Health as well as Science, Nature Biotechnology, Nature Communications, Science Translational Medicine, Journal of Clinical Investigation and Journal of Experimental Medicine.


He is a member of the Editorial Advisory Board, Journal Global Antimicrobial Resistance. He was formerly an associate editor, BMC Infectious Diseases and Scientific Reports, and a member of the editorial board, JAC-Antimicrobial Resistance.


Professor Lye is President of the College of Physicians, Singapore and Society of Infectious Disease (Singapore). He is an advocate for HIV prevention as Vice President of Action for AIDS. Internationally, he is secretary general, Asia Pacific Society of Clinical Microbiology and Infection, and a member of executive committee, International Society of Antimicrobial Chemotherapy, and council of International Society of Infectious Diseases.


Professor Lye's awards include: Dean's Award for Teaching Excellence, Yong Loo Lin School of Medicine, 2016; National Healthcare Group Team Recognition Award 2017, Silver, Hospital Acquired Infection Elimination Collaborative; Tan Tock Seng Hospital Milestone Award 2017, Antimicrobial Stewardship Programme; NHG Research Awards, Outstanding Research Impact Award 2019 and 2020; Fellow, International Society of Antimicrobial Chemotherapy, 2020; National Clinical Excellence Team Award, Ministry of Health, 2021; Dean's Award for Research, Lee Kong Chian School of Medicine, 2021.


His publications can be viewed at:

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