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NCID > For General Public > Ongoing Research

Ongoing Research

Ongoing Research

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Volunteer for Research

People who volunteer for medical research studies play a vital role in improving healthcare for everyone. Volunteers for these studies help to develop better ways of preventing, diagnosing and treating different health conditions. 

Our research at NCID focuses on preparing Singapore for infection outbreaks. Some of the studies we conduct are to develop new vaccines, new diagnostic tests, understand the pattern of different infections, and human challenge studies.

There are many different types of volunteers who participate in medical research. Volunteers may be healthy, at risk of developing a medical condition, or already diagnosed with a condition. Our research could not be conducted without the volunteers' valuable time and contributions.

If you are interested in being informed about studies that are looking for volunteers, please fill up the form below. We will contact you when there is a study you may be suitable for.

Information such as the purpose of the study and the responsibilities of volunteers who join these studies will be provided to those who are interested to be part of the clinical research. Participation in research is voluntary and you may stop at any time.

This volunteer database is hosted by the National Centre for Infectious Diseases (NCID) and supported by the Programme for Research in Epidemic Preparedness and REsponse (PREPARE). Together, we ensure your contributions are impactful, safe, and essential to advancing public health and preparing for future health challenges. 

Join now!​

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On-going studies​

Are you looking for a way to get involved in groundbreaking medical research and make a difference in the fight against infectious diseases? Join us in one of the on-going studies listed below.


​A Controlled Human Infection Model of Dengue (DEN-CHIM-01)

Despite extensive efforts at mosquito control, Singapore remains a country with a high dengue burden. There are no antiviral treatments for dengue, and highly effective vaccines are still in development.

This study aims to conduct a safe human infection challenge using an attenuated dengue virus (DENV) serotype 3 (DEN3) in healthy individuals to better understand how dengue causes infection and why that differs between individuals. Information from this study will be used to advance future trials of vaccines and treatments.

Study objectives are to:

  1. Determine the infection rate of the attenuated DEN3 in local uninfected and unvaccinated individuals.
  2. Characterise the clinical, haematological and virological response after controlled inoculation of the attenuated DEN3 challenge agent.
  3. Understand the cellular, humoral and innate immune response to dengue infection
  4. Explore the longitudinal immune response in the 3 years after challenge, including following subsequent dengue vaccination.

The study is currently on-going. For further information, please click here.

If you would like to register for the study, please click here.


Clinical validation and cost effectiveness study of a Self-administered Multi-pathogen Antigen Rapid Test (SMART)

The introduction of self-administered Antigen Rapid Tests (ART) during the COVID pandemic has significantly enhanced surveillance and diagnosis with minimal additional burden to the national laboratory testing system. Having local capability to rapidly roll out ART testing during the emergence of a novel respiratory pathogen is therefore critical to ensure pandemic preparedness.

This study aims to build local capacity by developing a prototype ART targeting 4 common viruses – Influenza A & B, SARS-CoV-2 and Respiratory Syncytial Virus (RSV) – and with the flexibility to substitute in new antibodies against novel pathogens when the need arises. Cost-effectiveness and household transmission data are collected remotely via a mobile app to assess the burden of respiratory viral diseases in the community.

In the SMART study, up to 1200 individuals aged 2 years and above will be enrolled across 3 hospital sites: TTSH/NCID, SGH and NUH.

The study is currently on-going.


​A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Immunogenicity, and Efficacy of V181 Dengue Vaccine in Healthy Participants 2 to 17 Years of Age (MOBILIZE-1)​


Dengue is a viral infection, spread to human via infected mosquito's bite(s). V181 vaccine is designed to be a single-dose vaccination, aim to provide protection against dengue infection, suitable for individual with previous dengue infection or had no prior

infection.

This study aims to study the safety and the effectiveness of this vaccine to prevent dengue in persons of ages 2-17 years old. NCID/TTSH is recruiting 16-17 years old individuals in good health to join in the study.

Study objectives are to:

  1. Test the safety of the experimental dengue vaccine
  2. See how well the body responds to it
  3. See how well it works to prevent dengue in healthy 2-17 year olds
There is a 5-year follow-up period to allow for an assessment of long-term vaccine safety and efficacy in this age group.

The study is currently on-going.



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​FAQs

Research Volunteers is a platform that connects individuals to clinical research studies focused on infectious diseases. Our team of experienced professionals works tirelessly to facilitate communication between researchers and volunteers, ensuring a seamless and rewarding experience for all involved.

1.      What is the time commitment for a research study?

The time commitment for each study may vary, but researchers will provide detailed information about the schedule and requirements during the recruitment process.

2.      Are there any risks involved in participating in a research study?

Researchers take every precaution to ensure the safety and well-being of participants. Before joining a study, you will receive detailed information about any potential risks and how they will be mitigated.

3.      Can I withdraw from a study at any time?

Yes, as a volunteer, you have the right to withdraw from a study at any time, for any reason, without facing any penalties. Just email us at [email protected]

Ready to join us in the fight against infectious diseases? Fill out our form​​ to get started on your research volunteer journey. Together, we can make a difference and help shape a healthier future for generations to come.​​






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