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NCID > For Healthcare Professionals > NCID Research Publications

NCID Research Publications

NCID Research Publications

 

  • ​Ahn M, Wang LF. Translation from bats to humans beyond infectious diseases. The Journal of experimental medicine. 2021 Sep 6;218(9):e20211223. doi: 10.1084/jem.20211223

  • ​Anderson DE, Cui J, Ye Q, Huang B, Tan Y, Jiang C, Zu W, Gong J, Liu W, Kim SY, Yan BG, Sigmundsson K, Lim XF, Ye F, Niu P, Irving AT, Zhang H, Tang Y, Zhou X, Wang Y, Tan W, Wang LF, Tan X. Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy. Proceedings of the National Academy of Sciences of the United States of America. 2021 Sep 28;118(39):e2104759118. doi: 10.1073/pnas.2104759118

  • ​Ang LW, Choy CY, Ng OT, Leo YS, Wong CS. Hepatitis C virus infection in HIV-infected men in Singapore, 2006-2018: incidence and associated factors. Sex Health. 2021 Jul;18(3):221-231. doi: 10.1071/SH20197.
  • ​Ang LW, Low C, Wong CS, Boudville IC, Toh MPHS, Archuleta S, Lee VJM, Leo YS, Chow A, Lin RT. Epidemiological factors associated with recent HIV infection among newly-diagnosed cases in Singapore, 2013–2017. BMC Public Health. 2021 Mar 2;21(1):430. https://doi.org/10.1186/s12889-021-10478-5

  • ​Ang LW, Ng OT, Boudville IC, Leo YS, Wong CS An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore. PLoS One. 2021 Jun 2;16(6):e0252320. doi: 10.1371/journal.pone.0252320. eCollection 2021.
  • ​Ang LW, Toh MPHS, Boudville IC, Wong CS, Archuleta S, Lee V, Chow A, Leo YS. Epidemiological factors associated with the absence of previous HIV testing among HIV-positive persons in Singapore, 2012-2017. BMJ Open
    . 2021 Aug 17;11(8):e050133. doi: 10.1136/bmjopen-2021-050133.
  • ​Aung AH, Lye DC, Cui L, Ooi CK, Chow AL. The “Timeless” use of Influenza-like Illness Criteria for influenza Detection in the Tropics. Int J Infect Dis. 2021 Mar 16:S1201-9712(21)00263-0. doi: 10.1016/j.ijid.2021.03.045. Epub ahead of print. Https://doi.org/10.1016/j.ijid.2021.03.045

  • ​Aung AH, Lye DC, Cui L, Ooi CK, Chow ALP. The "timeless" use of influenza-like illness criteria for influenza detection in the tropics. Int J Infect Dis. 2021 May;106:160-168. doi: 10.1016/j.ijid.2021.03.045. Epub 2021 Mar 16.
  • ​Barber BE, Grigg MJ, Piera KA, Chen Y, William T, Weinberg JB, Yeo TW, Anstey NM. Endothelial glycocalyx degradation and disease severity in Plasmodium vivax and Plasmodium knowlesi malaria. Sci Rep. 2021 May 7;11(1):9741. doi: 10.1038/s41598-021-88962-6.
  • ​Bijker R, Kumarasamy N, Kiertiburanakul S, Pujari S, Ng OT, Sun LP, Merati TP, Van Nguyen K, Lee MP, Cuong DD, Chan YJ, Choi JY, Ross J, Law M, Asia-Pacific I. An expanded HIV care cascade: ART uptake, viral load suppression and comorbidity monitoring among adults living with HIV in Asia. Antivir Ther. 2021 Jan 19. doi: 10.3851/IMP3379. Epub ahead of print. https://doi.org/10.3851/IMP3379

  • ​Chen SL, Ding Y, Apisarnthanarak A, Kalimuddin S, Archuleta S, Omar SFS, De PP, Koh TH, Chew KL, Atiya N, Suwantarat N, Velayuthan RD, Wong JGX, Lye DC. Author Correction: The higher prevalence of extended spectrum beta-lactamases among Escherichia coli ST131 in Southeast Asia is driven by expansion of a single, locally prevalent subclone. Sci Rep. 2021 Apr 14;11(1):8563. doi: 10.1038/s41598-021-87312-w
  • ​​Chew KL, Octavia S, Go J, Yeoh SF, Teo J. MIC Distributions of Routinely Tested Antimicrobials and of Rifabutin, Eravacycline, Delafloxacin, Clofazimine, and Bedaquiline for Mycobacterium fortuitum. Antimicrobial agents and chemotherapy. 2021 Sep 17;65(10):e0059321. doi: 10.1128/AAC.00593-21

  • ​Chew KL, Octavia S, Lai D, Lin RTP, Teo JWP. Genomic Characterization of Klebsiella quasipneumoniae from Clinical Specimens in Singapore. Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0041221. doi: 10.1128/AAC.00412-21. Epub 2021 Jul 16.
  • Chew KL, Octavia S, Yeoh SF, Teo JWP. In Vitro Synergy Testing of Eravacycline in Combination with Clarithromycin and Rifabutin against Mycobacterium abscessus Complex. Microbiology spectrum. 2021 Sep 3;9(1):e0004521. doi: 10.1128/Spectrum.00045-21

  • ​Chew KL, Octavia S, Yeoh SF, Teo JWP. MIC Values of Iclaprim and Lefamulin against Mycobacterium abscessus Complex. Antimicrobial agents and chemotherapy. 2021 Sep 17;65(10):e0061921. doi: 10.1128/AAC.00619-21

  • ​Chia PY, Htun HL, Leo YS, Lye DC. Safety of temporary interruption of antiplatelet therapy in dengue fever with thrombocytopenia. J Infect. 2021 Feb; 82(2):270-275. https://doi.org/10.1016/j.jinf.2020.10.038

  • ​Chong CS, Limviphuvadh V, Maurer-Stroh S. Global spectrum of population-specific common missense variation in cytochrome P450 pharmacogenes. Human mutation. 2021 Sep;42(9):1107-1123. doi: 10.1002/humu.24243
  • ​Fernández-Huerta M, Solomon D, Tan RKJ. Research news in clinical context. Sexually transmitted infections. 2021 Sep;97(6):395-396. doi: 10.1136/sextrans-2020-054858

  • ​Gan SH, KhinMar KW, Ang LW, Lim LKY, Sng LH, Wang YT, Chee CBE. Recurrent Tuberculosis Disease in Singapore. Open Forum Infect Dis. 2021 Jun 27;8(7):ofab340. doi: 10.1093/ofid/ofab340. eCollection 2021 Jul.
  • ​Goggi JL, Claser C, Hartimath SV, Hor PX, Tan PW, Ramasamy B, Abdul Rahman H, Cheng P, Chang ZW, Nguee SYT, Tang JR, Robins EG, Renia L. PET Imaging of Translocator Protein as a Marker of Malaria-Associated Lung Inflammation. Infection and immunity. 2021 Sep 16;89(10):e0002421. doi: 10.1128/IAI.00024-21
  • ​Goh JJN, Behn J, Chong CS, Zhong G, Maurer-Stroh S, Fan H, Loo LH. Structure-based virtual screening of CYP1A1 inhibitors: towards rapid tier-one assessment of potential developmental toxicants. Archives of toxicology. 2021 Sep;95(9):3031-3048. doi: 10.1007/s00204-021-03111-2
  • ​Griva K, Chia JMX, Goh ZZS, Wong YP, Loei J, Thach TQ, Chua WB, Khan BA. Effectiveness of a brief positive skills intervention to improve psychological adjustment in patients with end-stage kidney disease newly initiated on haemodialysis: protocol for a randomised controlled trial (HED-Start). BMJ open. 2021 Sep 21;11(9):e053588. doi: 10.1136/bmjopen-2021-053588
  • ​Han WM, Jiamsakul A, Salleh NAM, Choi JY, Huy BV, Yunihastuti E, Do CD, Merati TP, Gani YM, Kiertiburanakul S, Zhang F, Chan YJ, Lee MP, Chaiwarith R, Ng OT, Khusuwan S, Ditangco R, Kumarasamy N, Sangle S, Ross J, Avihingsanon A; TREAT Asia HIV Observational Database (TAHOD) of the International Epidemiology Databases to Evaluate AIDS (IeDEA) Asia-Pacific Group. HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia-Pacific region: a longitudinal cohort study. J Int AIDS Soc. 2021 May;24(5):e25736. doi: 10.1002/jia2.25736. PMID: 34021711.
  • ​Jolene Ee Ling Oon, Brenda Salada, Yin Shan Lim, Sophia Archuleta, Dale Fisher. Safety and efficacy of a 5-minute infusion versus the standard 30-minute infusion for antibiotics in an outpatient setting International Journal of Infectious Diseases. 2021-09-01;110(N.A):160-161. doi: 10.1016/j.ijid.2021.07.018

  • ​Kanitthamniyom P, Hon PY, Zhou A, Abdad MY, Leow ZY, Yazid NB, Xun VL, Vasoo S, Zhang Y. A 3D-printed magnetic digital microfluidic diagnostic platform for rapid colorimetric sensing of carbapenemase-producing Enterobacteriaceae. Microsystems & Nanoengineering. 2021 Jun 12;7(1):1-2.
  • ​Kwak ML, Chavatte JM, Chew KL, Lee BPY. Emergence of the zoonotic tick Dermacentor (Indocentor) auratus Supino, 1897 (Acari: Ixodidae) in Singapore. Ticks Tick Borne Dis. 2021 Jan;12(1):101574. https://doi.org/10.1016/j.ttbdis.2020.101574

  • ​Lau WH, White NJ, Yeo TW, Gruen RL, Pervushin K. Tracking oxidation-induced alterations in fibrin clot formation by NMR-based methods. Sci Rep. 2021 Aug 3;11(1):15691. doi: 10.1038/s41598-021-94401-3.
  • ​Lee TH, Lye DC, Chung DR, Thamlikitkul V, Lu M, Wong AT, Hsueh PR, Wang H, Cooper C, Wong JG, Shimono N, Pham VH, Perera J, Yang YH, Shibl AM, Kim SH, Hsu LY, Song JH.Antimicrobial stewardship capacity and manpower needs in the Asia Pacific. J Glob Antimicrob Resist. 2021 Mar; 24:387-394. https://doi.org/10.1016/j.jgar.2021.01.013

  • ​Lee IR, Thein TL, Ang LW, Ding Y, Lim JJ, Bok CF, Mukherjee S, Titin C, Kalimuddin S, Archuleta S, Lye DC. Cefazolin versus ceftriaxone as definitive treatment for Klebsiella pneumoniae bacteraemia: a retrospective multicentre study in Singapore. J Antimicrob Chemother. 2021 Jan 27:dkab009. doi: 10.1093/jac/dkab009. Epub ahead of print. https://doi.org/10.1093/jac/dkab009

  • ​Li C, Av-Shalom TV, Tan JWG, Kwah JS, Chng KR, Nagarajan N. BEEM-Static: Accurate inference of ecological interactions from cross-sectional microbiome data. PLoS computational biology. 2021 Sep;17(9):e1009343. doi: 10.1371/journal.pcbi.1009343
  • ​Liang En W, Ding CSL, Suresh KN, Lim PL. A Bedbound 71-Year-Old Singaporean Male Nursing Home Resident With An Ulcerating Perianal Mass. Clin Infect Dis. 2021 Feb 16;72(4):718-719. https://doi.org/10.1093/cid/ciaa916

  • ​Liao W, De Wang L, Li D, Du FL, Long D, Liu Y, Ng O, Zhang W. High Prevalence of 16s rRNA Methylase Genes Among Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae Isolates in a Chinese Tertiary Hospital. Microb Drug Resist. 2021 Jan;27(1):44-52. https://doi.org/10.1089/mdr.2019.0482

  • ​Lim JM, Duong MC, Cook AR, Hsu LY, Tam CC. Public knowledge, attitudes and practices related to antibiotic use and resistance in Singapore: a cross-sectional population survey. BMJ open. 2021 Sep 13;11(9):e048157. doi: 10.1136/bmjopen-2020-048157

  • ​Lim JT, Dickens BS, Tan KW, Koo JR, Seah A, Ho SH, Ong J, Rajarethinam J, Soh S, Cook AR, Ng LC. Hyperendemicity associated with increased dengue burden. Journal of the Royal Society, Interface. 2021 Sep;18(182):20210565. doi: 10.1098/rsif.2021.0565

  • ​Low SL, Leo YS, Lai YL, Lam S, Tan HH, Wong JCC, Tan LK, Ng LC. Evaluation of eight commercial Zika virus IgM and IgG serology assays for diagnostics and research. PLoS One. 2021 Jan 26;16(1):e0244601. https://doi.org/10.1371/journal.pone.0244601

  • ​Luo L, Payne M, Kaur S, Hu D, Cheney L, Octavia S, Wang Q, Tanaka MM, Sintchenko V, Lan R. Elucidation of global and national genomic epidemiology of Salmonella enterica serovar Enteritidis through multilevel genome typing. Microb Genom. 2021 Jul;7(7). doi: 10.1099/mgen.0.000605.
  • ​Macleod CK, Butcher R, Javati S, Gwyn S, Jonduo M, Abdad MY, Roberts CH, Keys D, Koim SP, Ko R, Garap J, Pahau D, Houinei W, Martin DL, Pomat WS, Solomon AW. Trachoma, Anti-Pgp3 Serology, and Ocular Chlamydia trachomatis Infection in Papua New Guinea. Clin Infect Dis. 2021 Feb 1;72(3):423-430. https://doi.org/10.1093/cid/ciaa042

  • ​Malleret B, El Sahili A, Tay MZ, Carissimo G, Ong ASM, Novera W, Lin J, Suwanarusk R, Kosaisavee V, Chu TTT, Sinha A, Howland SW, Fan Y, Gruszczyk J, Tham WH, Colin Y, Maurer-Stroh S, Snounou G, Ng LFP, Chan JKY, Chacko AM, Lescar J, Chandramohanadas R, Nosten F, Russell B, Rénia L. Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells. Nat Microbiol. 2021 Aug;6(8):991-999. doi: 10.1038/s41564-021-00939-3. Epub 2021 Jul 22.
  • ​Marimuthu K, Mo Y, Ling ML, Hernandez-Koutoucheva A, Fenlon SN, Bertrand D, Lye DC, Ang BSP, Perencevich E, Ng OT, Cooper BS, Nagarajan N, Chen SL, Barkham T. Household transmission of carbapenemase-producing Enterobacteriaceae: a prospective cohort study.  J Antimicrob Chemother. 2021 Jan 8:dkaa561. doi: 10.1093/jac/dkaa561. Epub ahead of print. https://doi.org/10.1093/jac/dkaa561

  • ​Marimuthu K, Mo Y, Ling ML, Hernandez-Koutoucheva A, Fenlon SN, Bertrand D, Lye DC, Ang BSP, Perencevich E, Ng OT, Cooper BS, Nagarajan N, Chen SL, Barkham T. Household transmission of carbapenemase-producing Enterobacteriaceae: a prospective cohort study.  J Antimicrob Chemother. 2021 Apr 13;76(5):1299-1302. doi: 10.1093/jac/dkaa561
  • ​Matsunaga KI, Kimoto M, Lim VW, Thein TL, Vasoo S, Leo YS, Sun W, Hirao I. Competitive ELISA for a serologic test to detect dengue serotype-specific anti-NS1 IgGs using high-affinity UB-DNA aptamers. Scientific reports. 2021 Sep 9;11(1):18000. doi: 10.1038/s41598-021-97339-8

  • ​Miow QH, Vallejo AF, Wang Y, Hong JM, Bai C, Teo FS, Wang AD, Loh HR, Tan TZ, Ding Y, She HW, Gan SH, Paton NI, Lum J, Tay A, Chee CB, Tambyah PA, Polak ME, Wang YT, Singhal A, Elkington PT, Friedland JS, Ong CW. Doxycycline host-directed therapy in human pulmonary tuberculosis. J Clin Invest. 2021 Aug 2;131(15):e141895. doi: 10.1172/JCI141895.
  • ​Molton JS, Lee IR, Bertrand D, Ding Y, Kalimuddin S, Lye DC, Nagarajan N, Gan YH, Archuleta S. Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners. Int J Infect Dis. 2021 Jun;107:1-4. doi: 10.1016/j.ijid.2021.04.012. Epub 2021 Apr 16.
  • ​Ng TM, Heng ST, Oon J, Chan M, Tam VH. Validation of Vancomycin Dosing Guidance During Transition of Care. J Clin Pharmacol. 2021 Jun;61(6):806-809. doi: 10.1002/jcph.1793. Epub 2020 Dec 16.
  • ​Ross J, Jiamsakul A, Kumarasamy N, Azwa I, Merati TP, Do CD, Lee MP, Ly PS, Yunihastuti E, Nguyen KV, Ditangco R, Ng OT, Choi JY, Oka S, Sohn AH, Law M. Virological failure and HIV drug resistance among adults living with HIV on second-line antiretroviral therapy in the Asia-Pacific. HIV Med. 2021 Mar;22(3):201-211. doi: 10.1111/hiv.13006. Epub 2020 Nov 5.
  • ​Rouers A, Appana R, Chevrier M, Lum J, Lau MC, Tan L, Lpy T, Tay A, Sethi R, Sathiakumar D, Kaur K, Bohme J, Leo YS, Renia L, Howland SW, Singhal A, Chen J, Fink K. CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function. iScience. 2021 May; 24(5):102482. doi: 10.1016/j.isci.2021.102482
  • ​Rouers A, Chng MHY, Lee B, Rajapakse MP, Kaur K, Toh YX, Sathiakumar D, Loy T, Thein TL, Lim VWX, Singhal A, Yeo TW, Leo YS, Vora KA, Casimiro D, Lim B, Tucker-Kellogg L, Rivino L, Newell EW, Fink K. Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection. Cell Rep Med. 2021 May 18;2(5):100278. doi: 10.1016/j.xcrm.2021.100278
  • ​Sim JXY, Gan ES, Tan HC, Choy MM, Wong HM, Tan BH, Kee T, Ho QY, Thangaraju S, Lin RTP, Ooi EE, Low JG. Aviremic organ transplant dengue virus transmission - A case report. Am J Transplant. 2021 May;21(5):1944-1947. doi: 10.1111/ajt.16540. Epub 2021 Mar 6.
  • ​Sirota FL, Maurer-Stroh S, Li Z, Eisenhaber F, Eisenhaber B. Functional Classification of Super-Large Families of Enzymes Based on Substrate Binding Pocket Residues for Biocatalysis and Enzyme Engineering Applications. Front Bioeng Biotechnol. 2021 Aug 2;9:701120. doi: 10.3389/fbioe.2021.701120. eCollection 2021.
  • ​Stewart AG, Paterson DL, Young B, Lye DC, Davis JS, Schneider K, Yilmaz M, Dinleyici R, Runnegar N, Henderson A, Archuleta S, Kalimuddin S, Forde BM, Chatfield MD, Bauer MJ, Lipman J, Harris-Brown T, Harris PNA; MERINO Trial Investigators and the Australasian Society for Infectious Disease Clinical Research Network (ASID-CRN). Meropenem Versus Piperacillin-Tazobactam for Definitive Treatment of Bloodstream Infections Caused by AmpC β-Lactamase-Producing Enterobacter spp, Citrobacter freundii, Morganella morganii, Providencia spp, or Serratia marcescens: A Pilot Multicenter Randomized Controlled Trial (MERINO-2). Open Forum Infect Dis. 2021 Aug 2;8(8):ofab387. doi: 10.1093/ofid/ofab387. eCollection 2021 Aug.
  • ​Si Z, Hou Z, Vikhe YS, Thappeta KRV, Marimuthu K, De PP, Ng OT, Li P, Zhu Y, Pethe K, Chan-Park MB. Antimicrobial Effect of a Novel Chitosan Derivative and Its Synergistic Effect with Antibiotics. ACS Appl Mater Interfaces. 2021 Jan 20;13(2):3237-3245. https://doi.org/10.1021/acsami.0c20881

  • ​Tan RKJ, Chan YY, Bin Ibrahim MA, Ho LP, Lim OZ, Choong BCH, Chio MT, Chen MI, Wong CM. Potential interactions between the pathways to diagnosis of HIV and other STIs and HIV self-testing: insights from a qualitative study of gay, bisexual and other men who have sex with men in Singapore. Sex Transm Infect. 2021 May;97(3):215-220. doi: 10.1136/sextrans-2020-054623. Epub 2020 Oct 21.
  • ​Tan RKJ, Wang Y, Prem K, Harrison-Quintana J, Teo AKJ, Kaur N, Cook AR, Chen MI, Wong CS. HIV Pre-Exposure Prophylaxis, Condoms, or Both? Insights on Risk Compensation Through a Discrete Choice Experiment and Latent Class Analysis Among Men Who Have Sex With Men. Value Health. 2021 May;24(5):714-723. doi: 10.1016/j.jval.2020.11.023. Epub 2021 Mar 22.
  • ​Tan RKJ, Wang Y, Prem K, Harrison-Quintana J, Teo AKJ, Kaur N, Cook AR, Chen MIC, Wong CS. HIV Pre-exposure Prophylaxis, Condoms, or Both? Insights on Risk Compensation Through a Discrete Choice Experiment and Latent Class Analysis Among Men Who Have Sex With Men. in print. https://doi.org/10.1016/j.jval.2020.11.023

  • ​Tan YR, Kaur N, Ye AJ, Zhang Y, Lim JXZ, Tan RKJ, Ho LP, Chen MI, Wong ML, Wong CS, Yap P. Perceptions of an HIV self-testing intervention and its potential role in addressing the barriers to HIV testing among at-risk heterosexual men: a qualitative analysis. Sex Transm Infect. 2021 Jan 15:sextrans-2020-054773. doi: 10.1136/sextrans-2020-054773. Epub ahead of print. https://doi.org/10.1136/sextrans-2020-054773

  • ​Teng VYM, Chua YT, Lai EEN, Mukherjee S, Michaels J, Wong CS, Leo YS, Young B, Archuleta S, Ong CWM. Lack of latent tuberculosis screening in HIV patients and delay in Anti-Retroviral Therapy initiation in HIV-TB co-infection: A 11-year study in an intermediate TB-burden country. in print. https://doi.org/10.1101.2021.02.15.21251801

  • Thorel M, Chavatte JM, Landau I, Lemberger K, Leclerc A. First case of Plasmodium relictum lineage pGRW11 infection in a captive-bred common eider (Somateria Mollissima) in Europe. Vet Parasitol Reg Stud Reports. 2021 Jan;23:100529. https://doi.org/10.1016/j.vprsr.2020.100529

  • ​Wong TTC, Yong X, Tung JSZ, Lee BJY, Chan JMX, Du R, Yeo TW, Yeo GSH. Prediction of labour onset in women who present with symptoms of preterm labour using cervical length. BMC Pregnancy Childbirth. 2021 May 5;21(1):359. doi: 10.1186/s12884-021-03828-z.
  • ​Wu Y, Raju C, Hou Z, Si Z, Xu C, Pranantyo D, Marimuthu K, De PP, Ng OT, Pethe K, Kang ET, Chan-Park MB. Mixed-charge pseudo-zwitterionic copolymer brush as broad spectrum antibiofilm coating. Biomaterials. 2021 Jun;273:120794. doi: 10.1016/j.biomaterials.2021.120794. Epub 2021 Apr 5.
  • ​Yap TL, Hong SY, Soh JH, Ravichandraprabhu L, Lim VWX, Chan HM, Ong TZX, Chua YP, Koh SE, Wang H, Leo YS, Ying JY, Sun W. Engineered NS1 for Sensitive, Specific Zika Virus Diagnosis from Patient Serology. Emerg Infect Dis. 2021 May;27(5):1427-1437. doi: 10.3201/eid2705.190121.

 


















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