SharePoint
A- A A+
NCID > About NCID > Our Departments > National Public Health Laboratory

National Public Health Laboratory

National Public Health Laboratory

The National Public Health Laboratory (NPHL) was set up in March 2009 as part of the Communicable Disease Division with the Ministry of Health (MOH), Singapore. NPHL provides specialised laboratory tests to track changes in existing organisms, detect new and re-emerging diseases and respond to outbreaks. In the past, NPHL has supported MOH in outbreak investigations, including investigations into the H1N1 pandemic in 2009, the Chikungunya outbreak and the Zika outbreak in 2016.

Currently, NPHL is actively involved in the lab surveillance and preparedness for highly infectious pathogens, such as MERS-CoV, H7N9 and Ebola. With the formation of NCID, NPHL is now one of NCID’s public health units to be located at Level 13.  NPHL’s facilities will include a biosafety-level 3 (BSL3) containment facility which will be dedicated to the surveillance of infections of public health importance as well as the detection and identification of novel pathogens.

The mission of NPHL is to use the best possible science for the laboratory surveillance of infectious diseases and the investigation of outbreaks. NPHL works closely with its partners in government agencies, medical laboratories and research institutions to enable a coordinated and broad-based response to infectious threats



S/N
​Photo
​About The Individual
​Bio
​1

​Adjunct Professor Raymond Lin
Director 

Qualifications:
MBBS, FRCPA

Journals & Publications:
1.  Chew, K. L., Octavia, S., Lai, D., Lin, R. T. P., & Teoa, J. W. P. (2021). Genomic characterization of Klebsiella quasipneumoniae from clinical specimens in Singapore. Antimicrobial Agents and Chemotherapy, 65(8). doi:10.1128/AAC.00412-21

2. Young, B. E., Fong, S. -W., Chan, Y. -H., Mak, T. -M., Ang, L. W., Anderson, D. E., . . . Ng, L. F. P. (2020). Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study. LANCET, 396(10251), 603-611. doi:10.1016/S0140-6736(20)31757-8

3. Yong, S. E. F., Ng, O. T., Ho, Z. J. M., Mak, T. M., Marimuthu, K., Vasoo, S., . . . Leo, Y. S. (2020). Imported Monkeypox, Singapore. EMERGING INFECTIOUS DISEASES, 26(8), 1826-1830. doi:10.3201/eid2608.191387

4. Young, B. E., Ong, S. W. X., Kalimuddin, S., Low, J. G., Tan, S. Y., Loh, J., . . . Lye, D. C. (2020). Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 323(15), 1488-1494. doi:10.1001/jama.2020.3204

5. Ng, O. -T., Marimuthu, K., Chia, P. -Y., Koh, V., Chiew, C. J., Wang, L. D., . . . Thoon, K. -C. (2020). SARS-CoV-2 Infection among Travelers Returning from Wuhan, China. NEW ENGLAND JOURNAL OF MEDICINE, 382(15), 1476-1478. doi:10.1056/NEJMc2003100

​Adj Prof Raymond Lin started as a medical microbiologist at the Singapore General Hospital, then moved to KK Women’s and Children’s Hospital and later to the National University Hospital, where he still heads the microbiology laboratory. He started the National Public Health Laboratory (NPHL) under the Ministry of Health (MOH) in 2007, and this laboratory supports surveillance and outbreak investigation of communicable diseases in the country. The scope of the NPHL covers bacteria (e.g. salmonellae, Streptococcus pneumoniae, antimicrobial resistance), viruses (e.g. enterovirus, influenza viruses, HIV, influenza, biothreat agents) and parasites (e.g. malaria).

In addition to his work in public health and clinical microbiology, he is an advisor on Biosafety to the MOH, chairs the technical committee for medical testing under the Singapore Accreditation Council, and is a member of the research committee of the Genetic Modification Advisory Committee. He teaches at the National University of Singapore where he holds a conjoint appointment in the Department of Microbiology and Immunology. He has served in various roles for the World Health Organization (WHO), including chairing the Pandemic Influenza Preparedness Framework Advisory Group, being a member of the SARS-CoV-2 Laboratory Expert Network, contributor to several WHO guidelines and as Temporary Advisor for ad hoc meetings.

​2
​Dr Cui Lin
Senior Principal Scientific Officer

​3

Mr Roger Chua
Head, Laboratory Operations
 
Qualifications:
BSc (Hons), MSc (Management)



​Mr Roger Chua joined the National Public Health Laboratory (NPHL) after 5 years with National Healthcare Group Diagnostics. Prior to that, he was with the Biomedical Research Council under Agency for Science, Technology and Research where he served as Senior Officer (Grant Management). He has also served as Medical Technologist in Clinical Chemistry, Cytogenetics and Laboratory Reception at KK Women's and Children's Hospital. 

Mr Chua has more than 10 years of laboratory operations and management experience in primary and tertiary healthcare settings where he participated and completed projects involving design, retrofit and renovation of mobile radiology facilities, laboratory and/or X-ray facility at both public and private healthcare settings, project management for the set up of BSL2 laboratories and high containment facility, regulatory licenses, laboratory relocation projects, procurement and negotiation activities. He has experience in business process workflow improvement and implementation of quality management systems such as ISO 9001, OHSAS 18000 and ISO 15189. He is a Ministry of Health certified Biosafety Coordinator and attained International Federation of Biosafety Associations (IFBA) professional certification in Biorisk Management and Biological Risk Assessment. Currently, Mr Chua oversees and manages the laboratory operations at the NPHL. 

​4

Dr Carmen Low
Senior Scientific Officer
 
Qualifications:
PhD
 
Journals & Publications:
1. Ang LW, Low C, Wong CS, Boudville IC, Toh MPHS, Archuleta S, Lee VJM, Leo YS, Chow A, Lin RT. Epidemiological factors associated with recent HIV infection among newly-diagnosed cases in Singapore, 2013-2017. BMC Public Health, 2021 Mar 2;21(1):430. https://doi.org/10.1186/s12889-021-10478-5

2. Singapore HIV Congress 2021. HIV transmitted drug resistance surveillance: An update on newly-diagnosed cases in Singapore. Carmen Low.

3. Singapore HIV Congress 2019. Transmitted HIV drug resistance in treatment-naïve persons, newly-diagnosed individuals in Singapore. Carmen Low, Raymond Lin.

4. 10th Asia-Pacific Congress of Medical Virology, 15 to 18 October 2015. Surveillance of HIV recent infection and transmitted drug resistance of HIV-1 strains from newly-diagnosed, treatment-naïve persons in a Singaporean cohort. Carmen Low, Teo Meng Li, Liu Yan Yan, Cui Lin, Raymond Lin.

​Dr Carmen Low is a Senior Scientific Officer in the National Public Health Laboratory (NPHL). She is the team leader in HIV surveillance team that provides critical laboratory support to Ministry of Health's HIV/AIDS surveillance programme and National Centre for Infectious Diseases' National HIV Programme, working on projects that include the detection of recent infections, application of next generation sequencing solutions for drug resistance monitoring and epidemiological investigations. She received her PhD from the Department of Microbiology, National University of Singapore. She did her post-doctoral research with the Infectious Diseases Research Group in Singapore-MIT Alliance Research and Technology, working on Mycobacterium tuberculosis and environmental mycobacteria before joining the NPHL.
​5

​Dr Jean-Marc Chavatte
Senior Scientific Officer

Qualifications:
BSc, Maitrise, MSc, PhD

Journals & Publications:
1. Renia L., Goh Y.S., Rouers A., Le Bert N., Chia W.N., Chavatte J.-M., et al. (2022). Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose. NATURE COMMUNICATIONS, 13, 4615. 
doi: 10.1038/s41467-022-32312-1.

2. Poh X.Y., Tan C.W., Lee I.R., Chavatte J.-M., Fong S.W., Prince T, et al. (2022). Antibody Response of Heterologous vs Homologous Messenger RNA Vaccine Boosters Against the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant: Interim Results from the PRIBIVAC Study, a Randomized Clinical Trial (SARS-CoV-2). CLINICAL INFECTIOUS DISEASES, ciac345.
doi: 10.1093/cid/ciac345.

3. Goh Y.S., Chavatte J.-M., Lim J.L.A., Lee B., Hor P.X., Amrun S.N., et al. (2021). Sensitive detection of total anti-Spike antibodies and isotype switching in asymptomatic and symptomatic individuals with COVID-19. CELL REPORTS MEDICINE, 2, 2:100193. doi: 10.1016/j.xcrm.2021.100193.

4. Kwak M.L., Chavatte J.-M., Chew K.L., Lee B.P.Y.-H. (2021). Emergence of the zoonotic tick Dermacentor (Indocentor) auratus Supino, 1897 (Acari: Ixodidae) in Singapore. TICKS AND TICK-BORNE DISEASES, 12, 1, 101574. doi: 10.1016/j.ttbdis.2020.101574.

5. Chavatte J.-M., Snounou G. (2021). Controlled human malaria infection—Maker and breaker of dogma. PLOS MEDICINE, 18, 4, e1003591.
doi: 10.1371/journal.pmed.1003591. 

6. Lim P.-L., Chavatte J.-M., Vasoo S., Yang J. (2020). Imported Human Babesiosis, Singapore, 2018. EMERGING INFECTIOUS DISEASES, 26, 4:826-828. doi: 10.3201/eid2604.200025. 

7. Zhang E.X., Chavatte J.-M., See C.X.Y., Tow C., Wong J.Y., Khan K., et al. (2019). Assessment of the risk posed to Singapore by the emergence of artemisinin-resistant malaria in the Greater Mekong Subregion. WESTERN PACIFIC SURVEILLANCE AND RESPONSE JOURNAL, 10, 2, 6-13. doi: 10.5365/wpsar.2018.9.2.011.

8. Huggan P.J., Ng C.H., Ho J., Lin R.T.P.V., Chavatte J.-M. (2018). A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether-lumefantrine treatment. MALARIA JOURNAL, 17, 1, 35. doi: 10.1186/s12936-018-2180-1. 

9. Chavatte J.-M., Jureen R. (2017). Imported Asymptomatic Bancroftian filariasis discovered from a Plasmodium vivax infected patient: A case report from Singapore. CASE REPORTS IN INFECTIOUS DISEASES, ID 1972587. doi: 10.1155/2017/1972587.

10. Chavatte J.-M., Tan S.B.H., Snounou G, Lin RTPV. (2015). Molecular characterization of misidentified Plasmodium ovale imported cases in Singapore. MALARIA JOURNAL, 14, 454.
doi: 10.1186/s12936-015-0985-8

​Dr Jean-Marc Chavatte studied biology at the Lille Catholic University, France and obtained a BSc in General Biology. He pursued his curriculum focusing on environmental evaluation with a keen interest on wildlife and more particularly in Ornithology and Entomology; and he obtained a Maitrise in Biology of Populations and Ecosystems. Then he decided to equip himself with molecular tools and studied to obtain a MSc in Cellular and Molecular Biology at the University Pierre and Marie Curie, Paris, France. Using his background, he worked on mosquitos as vector of parasitic diseases. Then he specialised in parasitic Protozoa causing diseases such as Malaria and obtained a PhD in Parasitology from the University Pierre and Marie Curie, Paris, France. 

Dr Chavatte worked as Research Fellow in the Laboratory of Evolutionary Parasitology from the French National Centre for Scientific Research (CNRS), Paris, France where he studied the vector-parasite interactions. Then as Research Fellow in the Laboratory of Comparative Parasitology and Experimental Models of the National Museum of Natural History, Paris, France. There, he specialised into the morphology, systematic and phylogeny of Malaria and other parasitic Protozoa. He continued to study the host/parasite and the vector/parasite interactions on animal models and collaborated on immunological studies of Malaria.

He joined the National Public Health Laboratory (NPHL) in late 2009 as a Research Scientist. He set up the Parasitology section which hosts the Malaria Reference Centre for Singapore since 2010. As the section Scientific Officer in charge, he leads the laboratory Malaria surveillance programme, which includes case confirmation, epidemiology, outbreak investigations of Malaria in the country as well as antimalarial-drug resistance monitoring. He also organises the Malaria Parasite Proficiency Testing. Beside Malaria, Dr Chavatte continues to work and to provide support to Infectious Diseases clinicians on other parasites such as haematozoa, enteritic Protozoa, worms and ectoparasites.

Morphologist and microscopist, Dr Chavatte is also in charge of the Electron Microscopy team and platform in the NPHL.

At the beginning of the COVID-19 pandemic, Dr Chavatte contributed to the early development of detection and screening tools in the NPHL. Then he moved his focus to set up COVID-19 serological testing in the NPHL and participated in the evaluation of many kits and platforms. He established automation of the serological assays to ramp up the testing capabilities and help in outbreak investigations. Key player in the NPHL serological testing, he is overseeing the testing of National Sero-Surveillance samples and is collaborating in numerous COVID-19 infection and vaccines and serological studies.

​6

​Dr Michelle Ang
Senior Scientific Officer

Qualifications:
PhD

Journals & Publications:
1. Garcia Quesada M, Yang Y, Bennett JC, Hayford K, Zeger SL, … The Pserenade Team. Serotype Distribution of Remaining Pneumococcal Meningitis in the Mature PCV10/13 Period: Findings from the PSERENADE Project. Microorganisms. 2021 Apr 1;9(4):738.
doi:10.3390/microorganisms9040738. 

2. Marimuthu K, Ng OT, Cherng BPZ, Fong RKC, Pada SK, … CaPES Study Group. Antecedent Carbapenem Exposure as a Risk Factor for Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae and Carbapenemase-Producing Enterobacteriaceae. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e00845-19. doi:10.1128/AAC.00845-19. PMID: 31383670.

3. Ong CH, Ratnayake L, Ang MLT, Lin RTP, Chan DSG. Diagnostic Accuracy of BD Phoenix CPO Detect for Carbapenemase Production in 190 Enterobacteriaceae Isolates. J Clin Microbiol. 2018 Nov 27;56(12):e01043-18. doi:10.1128/JCM.01043-18. 

4. Lai Y, Purnima P, Ho M, Ang M, Deepak RN, … Lee V. Fatal Case of Diphtheria and Risk for Reemergence, Singapore. Emerg Infect Dis. 2018 Nov;24(11):2084-2086. 
doi: 10.3201/eid2411.180198.

5. Octavia S, Ang MLT, La MV, Zulaina S, Saat ZAAS, … Lin RTP. Retrospective genome-wide comparisons of Salmonella enterica serovar Enteritidis from suspected outbreaks in Singapore. Infect Genet Evol. 2018 Jul;61:229-233. 
doi: 10.1016/j.meegid.2018.04.004. Epub 2018 Apr 4. 

​Dr Michelle Ang obtained her PhD in Microbiology from the National University of Singapore in 2015, with a focus on the elucidation of the molecular mechanism of ethionamide resistance in Mycobacterium tuberculosis (TB). She further pursued her research interests in TB-associated drug discovery and resistance mechanisms as a Research Fellow in Lee Kong Chian School of Medicine, Nanyang Technological University for 1.5 years. With a strong desire to translate her research and work endeavours into more applied real-life settings, she joined the National Public Health Laboratory in 2016 as a Scientific Officer. Besides leading bacteriology-related laboratory surveillance programs including Streptococcus pneumoniae, Clostridioides difficile and Salmonella, she also supports the Ministry of Health’s Communicable Diseases Division and public hospitals in outbreak investigations. As whole genome sequencing (WGS) can provide increased resolution over traditional typing methods, she has also been actively involved in the implementation and use of WGS for public health surveillance and outbreak investigations of communicable diseases, including nationwide WGS for enhanced TB surveillance and contact tracing.
​7

Dr Grace Ngan Jie Yin  
Scientific Officer

Qualifications:
PhD in Microbiology

Journals & Publications:
1. GJY Ngan, LM Ng, RTP Lin, JWP Teo. 2010. Development of a novel multiplex PCR for the detection and differentiation of Salmonella enterica serovars Typhi and Paratyphi A. Research Microbiology 161(4):243-8. 

2. GJY Ngan, LM Ng, R Jureen, RTP Lin, JWP Teo. 2011. Development of multiplex PCR assays based on the 16S-23S rRNA internal transcribed spacer for the detection of clinically relevant nontuberculous mycobacteria. Letters in Applied Microbiology 52 (5): 546-54. 

3. MND Balm, GYJ Ngan, R Jureen, RTP Lin, JWP Teo. 2011. Molecular Characterization of Newly Emerged bla (KPC-2)-Producing Klebsiella pneumoniae in Singapore. Journal of Clinical Microbiology 50(2): 475-6. 

4. GJY Ngan, RTP Lin, JWP Teo. 2012. Utility of the Bruker Biotyper matrix-Assisted laser desorption ionization time-of-Flight mass spectrometer in a clinical microbiology laboratory. Pathology 44(5): 493-6. 

5. MND Balm, GJY Ngan, R Jureen, RTP Lin, JWP Teo. 2013. OXA-181-producing Klebsiella pneumoniae establishing in Singapore. BMC Infectious Diseases 13(1):58

​Dr Grace Ngan Jie Yin completed her Ph.D. at the National University of Singapore (NUS) in 2017. She specialised in the field of Microbiology, particularly in the drug discovery of Tuberculosis (TB). She discovered Bortezomib as a new lead compound in the pipeline of TB drug discovery during her PhD study.

Her passion for TB led her to go back to basic science research. She did her postdoctoral training with Assoc /Prof Sylvie Alonso in Life Science Institute, NUS. In the study to elucidate the functionality of a protein called HflX in TB, she confirmed the role of HflX in hypoxic stress adaptation, a critical physiological condition for TB to persist in the host. Her work was published in Proceedings of the National Academy of Sciences in 2021. 

Dr Ngan joined the National Public Health Laboratory in February 2021, striving to share her knowledge and passion for infectious diseases to benefit public health in Singapore. 

​8

​Dr Benny Yeo Ken Yee
Scientific Officer

Qualifications:
PhD



​Dr Benny Yeo studied Ph.D. at Lee Kong Chian, School of Medicine, Nanyang Technological University, where he specialised in Staphylococcus aureus metabolism research.

Dr Yeo started his work at the National Public Health Laboratory under the Ministry of Health in 2021, upon completion of his PhD studies, as a Scientific Officer. The scope of his work involves the surveillance of respiratory viruses which includes SARS-CoV-2 and Influenza virus.

​9

​Dr Daniel Lim
Scientific Officer

Qualifications:
BSc (Hons), PhD

Journals & Publications:
1. Gamage AM, Liao C, Cheah IK, Chen Y, Lim DRX, Ku JWK, Chee RSL, Gengenbacher M, Seebeck FP, Halliwell B, Gan YH. The proteobacterial species Burkholderia pseudomallei produces ergothioneine, which enhances virulence in mammalian infection. FASEB J. 2018 Jun 11:fj201800716.
doi:10.1096/fj.201800716

​Dr Daniel Lim studied Life Sciences at the National University of Singapore (NUS) with a specialisation in biomedical science, obtaining a Bachelor of Science with Honours (Distinction). He continued his post graduate studies in the Department of Biochemistry in NUS and obtained a PhD for his work on GSH-induced virulence in Enterobacteriaceae.

Dr Lim joined the National Public Health Laboratory under the Ministry of Health in 2021 and is currently overseeing surveillance of Hand, Foot, and Mouth disease, Hepatitis B/C/E and norovirus. He also help support the National Serosurveillance Program.
​10

​Dr Sharol Cho
Scientific Officer

Qualifications:
BSc (Hons), PhD 

Journals & Publications:
1. Ngan, J., Pasunooti, S., Tse, W., Meng, W., Ngan, S., Jia, H., Lin, J. Q., Ng, S. W., Jaafa, M. T., Cho, S., Lim, J., Koh, H., Abdul Ghani, N., Pethe, K., Sze, S. K., Lescar, J., & Alonso, S. (2021). HflX is a GTPase that controls hypoxia-induced replication arrest in slow-growing mycobacteria. Proceedings of the National Academy of Sciences of the United States of America, 118(12), e2006717118. DOI: 10.1073/pnas.2006717118

2. Lim, J., Koh, V., Cho, S., Periaswamy, B., Choi, D., Vacca, M., De Sessions, P. F., Kudela, P., Lubitz, W., Pastorin, G., & Alonso, S. (2019). Harnessing the Immunomodulatory Properties of Bacterial Ghosts to Boost the Anti-mycobacterial Protective Immunity. Frontiers in immunology, 10, 2737. DOI: 10.3389/fimmu.2019.02737

3. Cho, S., Han, J., James, S. J., Png, C. W., Weerasooriya, M., Alonso, S., & Zhang, Y. (2017). Dual-Specificity Phosphatase 12 Targets p38 MAP Kinase to Regulate Macrophage Response to Intracellular Bacterial Infection. Frontiers in immunology, 8, 1259. DOI: 10.3389/fimmu.2017.01259

​Dr Sharol Cho studied Life Sciences at the National University of Singapore (NUS), and specialised in biomedical sciences, obtaining Bachelor of Science with Honours (Distinction) in 2016. She then pursued her doctorate in NUS, in the department of Microbiology and Immunology and completed the programme in 2021. Her project focused on the regulatory functions of IRF3 in a pulmonary bacterial infection model. 

Dr Cho started work in the National Public Health Laboratory under the Ministry of Health in 2021, supporting bacterial surveillance and outbreak investigations.



​11

​Mr Siew Chern Chiang
Biosafety Coordinator, Principal Medical Technologist

Qualifications:
B.SC Molecular Biology, Curtin University, Australia
B.SC Information Tech, Southern Cross University, Australia

Journals & Publications:
1.Ribas, A., Jollivet, C., Morand, S., Thongmalayvong, B., Somphavong, S., Siew, C.C., Ting, P.J., Suputtamongkol, S., Saensombath, V., Sanguankiat, S. and Tan, B.H., 2017. Intestinal parasitic infections and environmental water contamination in a rural village of northern Lao PDR. The Korean journal of parasitology, 55(5), p.523.

2. Johansson, P., Yap, G., Low, H.T., Siew, C.C., Kek, R., Ng, L.C. and Bucht, G., 2010. Molecular characterization of two hantavirus strains from different rattus species in Singapore. Virology journal, 7(1), pp.1-9.

3. Johansson, P., Yap, G., Low, H.T., Siew, C.C., Kek, R., Ng, L.C. and Bucht, G., 2010. Molecular characterization of two hantavirus strains from different rattus species in Singapore. Virology journal, 7(1), pp.1-9.

4. Griffiths, J., Yeo, H.L., Yap, G., Mailepessov, D., Johansson, P., Low, H.T., Siew, C.C., Lam, P. and Ng, L.C., 2022. Survey of rodent-borne pathogens in Singapore reveals the circulation of Leptospira spp., Seoul hantavirus, and Rickettsia typhi. Scientific Reports, 12(1), pp.1-14.

5. Kreisberg, J.F., Ong, N.T., Krishna, A., Joseph, T.L., Wang, J., Ong, C., Ooi, H.A., Sung, J.C., Siew, C.C., Chang, G.C. and Biot, F., 2013. Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrobial agents and chemotherapy, 57(3), pp.1513-1517.

​Mr Siew Chern Chiang's scope of work involves basic research, applied research, environmental surveillance and working with highly infectious agents. He has over 20 years of invitro and invivo laboratory experience culminating as the biosafety coordinator overseeing high containment facilities. 
​12

​Dr Ding Yichen
Scientific Officer

Qualifications:
PhD in Microbiology

Journals & Publications:
1. Yichen Ding, Woei-Yuh Saw, Linda Wei Lin Tan, Don Kyin Nwe Moong, et al. Extended spectrum β-lactamase and mcr-1 Positive Escherichia coli from Gut Microbiota of Healthy Singaporeans. Applied and environmental microbiology (2021), pp.AEM-00488.

2. Yichen Ding, Woei-Yuh Saw, Linda Wei Lin Tan, Don Kyin Nwe Moong, et al. Emergence of tigecycline-and eravacycline-resistant Tet(X4)-producing Enterobacteriaceae in the gut microbiota of healthy Singaporeans. Journal of Antimicrobial Chemotherapy, 75.12 (2020): 3480-3484.

3. Yichen Ding*, Jeanette Teo, Daniela I. Drautz-Moses, Stephan C. Schuster, et al. Acquisition of Resistance to Carbapenem and Macrolide-mediated Quorum Sensing Inhibition by Pseudomonas aeruginosa via ICETn43716385 (2018), Communications Biology, doi:10.1038/s42003-018-0064-0. (*Corresponding author. Communications Biology first year anniversary collection)

4. Weixin Su*, Veerendra Kumar*, Yichen Ding*, et al. Ribosome protection by antibiotic resistance ATP-binding cassette protein (2018). PNAS, doi:10.1073/pnas.1803313115. (* Co-first authors)

5. Ke Wang, Yi-qiang Chen*, Liang Yang, May Margarette Salido, Jin-Liang Kong, Hong-jie Liang, Ziting Yao, Yan-tong Xie, Hua-yu Wu, Shuang-qi Cai, Daniela I Drautz-Moses, Stephan Christoph Schuster, Liang Yang, Yichen Ding*. The rapid in vivo evolution of Pseudomonas aeruginosa during ventilator-associated pneumonia patients leads to attenuated virulence (2017). Open Biology: 7-9 (* Corresponding authors)

Dr Ding Yichen received his PhD in Microbiology at Nanyang Technological University, and then worked at Temasek Life Sciences Laboratory as a research fellow. His research interest includes understanding antimicrobial resistance mechanisms and intra host evolution of pathogens using next-generation sequencing. He joined the National Public Health Laboratory (NPHL) as a scientific officer in January 2022, and his current role involves SARS-CoV-2 surveillance, whole genome sequencing (WGS)-based outbreak investigation of viral and bacterial pathogens, and supporting other teams in WGS data analysis.


















Last Updated on