The National Tuberculosis (TB) Programme (NTBP), previously known as the Singapore TB Elimination Programme (STEP), was launched by MOH in 1997 to strengthen the national TB prevention and care efforts in response to the then decade-long stagnation in the country's TB incidence rate.

Vision: A TB-free Singapore with people-centred care

Mission: Protect the people of Singapore from TB through
- Prompt diagnosis and management;
- Effective contact tracing and screening;
- Strong partnerships; and
- Sustainable strategies

The NTBP Registry administers the National TB notification registry and the national Treatment Surveillance Module which monitors the treatment progress and outcome of all TB cases in the country.

The TB Control Unit (TBCU) being the clinical arm of NTBP, functions as the national referral centre for TB evaluation and treatment. It manages 80% of the country's TB cases, the vast majority of whom are treated under Directly Observed Therapy (DOT).  Another major function of the TBCU is the screening of close contacts in households, workplaces and congregate settings (such as schools and prisons) for active and latent TB, and provision of preventive therapy for contacts found to have latent TB infection.